Scientist Curator - Genetic Drivers of Cancer

  • Job Reference: 80290322-2
  • Date Posted: 11 February 2019
  • Recruiter: The Wellcome Trust Sanger Institute
  • Location: Cambridge, Cambridgeshire
  • Salary: On Application
  • Sector: I.T. & Communications
  • Job Type: Permanent
  • Start Date: ASAP
  • Work Hours: Full Time

Job Description

Salary in the region of £36,737 - £44,451 (dependent on experience) plus excellent benefits. Permanent / Open Contract

We are seeking a motivated and experienced scientist in cancer molecular biology and genetics to lead the expansion and curation of the Cancer Gene Census at the Wellcome Sanger Institute within COSMIC (), a database of genetic mutations in cancer, a major resource in cancer research, widely used across informatics, diagnostic and pharmaceutical industries.

The Opportunity

COSMIC () is working with Open Targets () to expand the world's most comprehensive description of the genes causing human cancer, the Cancer Gene Census. This is an exciting position within the COSMIC team, where you will have the opportunity to explore & interpret a wide range of literature, database and analytic resources to create a complete landscape of genetic dysfunctions across all cancer types and explain which molecular mechanisms are most important in development of these diseases. Our first aim is to expand the Cancer Gene Census with new genes, and to generate full descriptive coverage of all Census genes with evidence of oncogenic activity. The Cancer Gene Census is frequently cited in publications and regularly used as a key data source in cancer genome analytics and databases; this project extends this high-profile resource, offering multiple opportunities for very citeable publications.

About you

You will work together with COSMIC scientific team, bringing a range of analytic, curation and literature techniques to describe the oncogenic impact of genes implicated in cancer. During this project, you will have substantial opportunities for learning and development, working closely with informaticians and cancer scientists in COSMIC, in the Sanger Institute, and software/database developers in Open Targets; informatic assistance is available to candidates with strong scientific expertise.

About us

The Wellcome Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists. Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health. We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. Our science is large-scale and organised into Programmes, led by our Faculty who conceive and deliver our science, and supported by our Scientific Operations teams responsible for all data production pipelines at the Institute.


A revolution is underway in health informatics, with genetics increasingly important in understanding human health and disease. COSMIC (), a database of genetic mutations in cancer, is a major resource in cancer research, used by over 3000 scientists every day across the informatics, diagnostic and pharmaceutical industries. We are expanding rapidly and developing a range of new services to support multiple academic and industrial research efforts.

Essential Skills

* PhD in Bioinformatic or Biosciences discipline (or equivalent experience)
* Substantial Knowledge and experience of cancer genetics and biology
* Experience with scientific literature and ability to interpret and summerise expmerimental findings
* Self-motivated, able to work independently and organise own workload
* Good communication skills both oral and written

Ideal Skills

* Data handling skills
* Experience of relational databases

Other information

Open Targets is a pioneering public-private initiative between GlaxoSmithKline (GSK), Biogen, Takeda, Celgene, Sanofi, EMBL-EBI (European Bioinformatics Institute) and the WSI (Wellcome Sanger Institute), located on the Wellcome Genome Campus in Hinxton, near Cambridge, UK.

Open Targets aims to generate evidence on the biological validity of therapeutic targets and provide an initial assessment of the likely effectiveness of pharmacological intervention on these targets, using genome-scale experiments and analysis. Open Targets aims to provide an R&D framework that applies to all aspects of human disease, to improve the success rate for discovering new medicines and share its data openly in the interests of accelerating drug discovery.

Our Benefits: Our employees have access to a comprehensive range of benefits and facilities

Genome Research Limited hold an Athena SWAN Bronze Award and will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.

Please include a covering letter and CV with your application

Closing date: 10th March 2019