Genomic technologies (ChIP-seq, EMSA, DAPA, ATAC-seq, DNA methylation, and others) are being applied in Dr. Harley's laboratory to reconcile genetic associations with the environmental causes of idiopathic autoimmune disorders with the goal to elucidate mechanisms initiating these pathological processes. The candidate would join a team that has uncovered unexpected and powerful associations of transcription factors with genetic loci, with the goal to establish the genetic mechanisms. The team in place has the strategic, informatic, clinical, and technical expertise to provide strong support for the candidate in addition to the other resources and personnel of the Center for Autoimmune Genomics and Etiology (CAGE). The disorders with direct relevance to this position include lupus, rheumatoid arthritis, multiple sclerosis, type 1 diabetes, inflammatory bowel disease, chronic lymphocytic leukemia, Hodgkin's disease, and many others.
Education, training, experience:
Qualifications: The ideal candidate will have a PhD with training in genetic epidemiology with a familiarity with genomic molecular laboratory methods (e.g., ChIP-seq, CRISPR-Cas9, EMSA, DAPA, etc.). Deep familiarity with genome wide association studies for any complex genetic disease phenotype would be important. Preference will be given to applicants with experience with informatic expertise, including genome wide association studies, the analysis of next generation sequence data, large genotyping datasets, and data mining, in general, along with demonstrated scholarly productivity by discovery and publication.
Additional instructions and information:
Please submit your application to Dr. Harley with the following information: A cover letter, a statement of interest, and a CV with contact details for 3 referees.
Contact: John Harley, MD, PhD
When applying online, please apply for Job Number: 99288
Please do not forget to mention Bio Careers when applying.