A postdoctoral research position is available in the laboratory of Dr. Natasha Caplen in the Genetics Branch, Center for Cancer Research, National Cancer Institute. Dr. Caplen's Laboratory conducts multidisciplinary and interdisciplinary research that uses RNAi and other DNA or RNA-based functional genomic technologies to interrogate specific aspects of the genetic, transcriptional, and cell-signaling alterations observed in cancer cells.
Our current research focuses on the development of new treatment strategies for cancers driven by fusion oncoproteins. Since only tumor cells express and depend on the products of fusion or chimeric oncogenes, a fusion transcript or protein represents an ideal molecular target. We hypothesize that proteins needed for the expression of fusion oncoproteins will reveal new therapeutic targets for tumors dependent on their oncogenic activity and potentially other cancers. Using functional genetic approaches coupled with molecular, biochemical, and cell biology-based methods our specific aims are to discover and characterize proteins required for the post-transcriptional or post-translational regulation of fusion oncoproteins. We are seeking self-motivated candidates interested in the study of protein post-translational modification, transcription factor biology, or RNA processing and splicing
Education, training, experience:
We are seeking self-motivated candidates with Ph.D. or M.D. degree, or equivalent, in molecular/cell biology or biochemistry, or related disciplines, ideally with additional training in the computational analysis of large-scale genome and transcriptome data. The candidate must have excellent verbal and written communication skills.